Introduction: The use of opioids has been increasing in operating room and intensive care
unit to provide perioperative analgesia as well as stable hemodynamics. However, many …

The lack of analgesic efficacy limits tramadol as a sole agent to treat severe pain after
surgery. However, it has a relative lack of respiratory depressant and constipating effects …

Background Rapid development of acute opioid tolerance is well established in animals and
is more likely to occur with large doses of short-acting drugs. The authors therefore tested …

Background Although intravenous morphine titration is widely used to obtain rapid and
complete postoperative pain relief, the relationship between measurement of pain and …

Background Opioid-induced delayed hyperalgesia and allodynia have been reported in
human and animal models. The authors evaluated the influence of different opioids used …

Background. Although remifentanil's short‐acting pharmacokinetic profile makes it well
suited for procedures during which a brief period of intense analgesia is required, setting up …

BACKGROUND: IV morphine titration (IMT) is widely used in the postanesthesia care unit to
achieve pain relief. Numerous factors contribute to variability in postoperative pain or …

Background Emergence from anaesthesia and tracheal extubation can be associated with
hyperdynamic circulatory responses. We examined the effects of maintaining a remifentanil …

Background. Sufentanil and remifentanil are characterized by two different pharmacokinetic
profiles. The aim of this study was to compare the effects of sufentanil and remifentanil …

Background Pregabalin is widely used perioperatively. The authors explored the effects of
pregabalin, remifentanil, and their combination on experimental pain, ventilatory, and …