The dopamine hypothesis of drug addiction: hypodopaminergic state
Drug addiction is a brain disorder caused by the repetitive use of various chemicals which
alter normal functioning of the central nervous system with consequent behavioral …
alter normal functioning of the central nervous system with consequent behavioral …
Preclinical evaluation of pharmacotherapies for treatment of cocaine and opioid abuse using drug self-administration procedures
NK Mello, SS Negus - Neuropsychopharmacology, 1996 - nature.com
Drug abuse is a major public health problem, and the relationship between intravenous drug
abuse and AIDS underscores the need for more effective treatment medications. Animal …
abuse and AIDS underscores the need for more effective treatment medications. Animal …
Agonist-like, replacement pharmacotherapy for stimulant abuse and dependence
J Grabowski, J Shearer, J Merrill, SS Negus - Addictive behaviors, 2004 - Elsevier
Stimulant abuse and dependence are disproportionately problematic due to the combination
of legal and social issues added to the serious behavioural and biological features of the …
of legal and social issues added to the serious behavioural and biological features of the …
Intravenous self-administration of morphine by naive mice
HE Criswell, A Ridings - Pharmacology Biochemistry and Behavior, 1983 - Elsevier
A simple method for IV self-administration of drugs by mice is described. When morphine
(0.5 mg/kg) was made contingent on a nosepoke response, naive mice increased their rate …
(0.5 mg/kg) was made contingent on a nosepoke response, naive mice increased their rate …
Effects of 2β-propanoyl-3β-(4-tolyl)-tropane (PTT) on the self-administration of cocaine, heroin, and cocaine/heroin combinations in rats
GM Sizemore, HML Davies, TJ Martin… - Drug and alcohol …, 2004 - Elsevier
Pharmacotherapies utilizing long-acting agonists and mixed function agonists–antagonists
have been successful in the treatment of opiate addiction but no comparable treatment …
have been successful in the treatment of opiate addiction but no comparable treatment …
A simple methodology for opiate self-administration and electrical brain stimulation in the mouse
HE Criswell - Life sciences, 1982 - Elsevier
A laboratory mouse can be partially restrained by placing it inside a cage with its tail
protruding through a hole in one wall and taped to a surface outside of the cage. The mouse …
protruding through a hole in one wall and taped to a surface outside of the cage. The mouse …
Human experimental therapeutic models in opioid dependence: translational research advances and implications
MK Greenwald - Trends in Substance Abuse Research, 2007 - books.google.com
This chapter selectively discusses recent advances in human experimental models relating
to the treatment of opioid dependence. I critically review three independent lines of research …
to the treatment of opioid dependence. I critically review three independent lines of research …
Self administration of cocaine in monkeys receiving LAAM acutely or chronically
LR Gerak, R Galici, CP France - Physiology & behavior, 2008 - Elsevier
GERAK, LR, R. GALICI AND CP FRANCE. Self administration of cocaine in monkeys
receiving LAAM acutely or chronically. PHYSIOL BEHAV 00 (0) 000-000, 2007. Polydrug …
receiving LAAM acutely or chronically. PHYSIOL BEHAV 00 (0) 000-000, 2007. Polydrug …
Экспериментальные модели наркозависимости
НВ Михневич - Сибирский научный медицинский журнал, 2004 - cyberleninka.ru
В связи с объективной потребностью изучения приr роды и механизмов
наркозависимости естественно возr никновение необходимости моделирования этого …
наркозависимости естественно возr никновение необходимости моделирования этого …