Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms

YQ He, CC Zhou, LY Yu, L Wang, JL Deng… - Pharmacological …, 2021 - Elsevier
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome
(ARDS) as common life-threatening lung diseases with high mortality rates are mostly …

Composition, structure and mechanical properties define performance of pulmonary surfactant membranes and films

E Parra, J Pérez-Gil - Chemistry and physics of lipids, 2015 - Elsevier
The respiratory surface in the mammalian lung is stabilized by pulmonary surfactant, a
membrane-based system composed of multiple lipids and specific proteins, the primary …

[HTML][HTML] Structure of pulmonary surfactant membranes and films: the role of proteins and lipid–protein interactions

J Pérez-Gil - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2008 - Elsevier
The pulmonary surfactant system constitutes an excellent example of how dynamic
membrane polymorphism governs some biological functions through specific lipid–lipid …

[HTML][HTML] A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant

E Keating, YY Zuo, SM Tadayyon, NO Petersen… - … et Biophysica Acta (BBA …, 2012 - Elsevier
The exact mechanism by which pulmonary surfactant films reach the very low surface
tensions required to stabilize the alveoli at end expiration remains uncertain. We utilized the …

Soluble innate immune pattern-recognition proteins for clearing dying cells and cellular components: implications on exacerbating or resolving inflammation

ML Litvack, N Palaniyar - Innate immunity, 2010 - journals.sagepub.com
Soluble innate immune pattern-recognition proteins (sPRPs) identify non-self or altered-self
molecular patterns. Dying cells often display altered-self arrays of molecules on their …

Lung injury induced by sepsis: lessons learned from large animal models and future directions for treatment

B Sadowitz, S Roy, LA Gatto, N Habashi… - Expert review of anti …, 2011 - Taylor & Francis
Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) remain common
complications of sepsis. Unfortunately, development of effective pharmacologic and …

[HTML][HTML] Pharmacotherapy for prevention and treatment of acute respiratory distress syndrome: current and experimental approaches

KJ Bosma, R Taneja, JF Lewis - Drugs, 2010 - Springer
The acute respiratory distress syndrome (ARDS) arises from direct and indirect injury to the
lungs and results in a life-threatening form of respiratory failure in a heterogeneous, critically …

Lung remodeling associated with recovery from acute lung injury

SE Gill, CM Yamashita, RAW Veldhuizen - Cell and tissue research, 2017 - Springer
Acute respiratory distress syndrome (ARDS) is a disease with a variety of causes and is
defined by severe hypoxemia. Whereas ARDS carries a mortality of approximately 30 …

[HTML][HTML] Treatments for pulmonary ricin intoxication: current aspects and future prospects

Y Gal, O Mazor, R Falach, A Sapoznikov, C Kronman… - Toxins, 2017 - mdpi.com
Ricin, a plant-derived toxin originating from the seeds of Ricinus communis (castor beans),
is one of the most lethal toxins known, particularly if inhaled. Ricin is considered a potential …

Recent developments of small molecules with anti-inflammatory activities for the treatment of acute lung injury

T Chen, G Zhu, X Meng, X Zhang - European Journal of Medicinal …, 2020 - Elsevier
Abstract Acute Lung Injury (ALI) can be caused by various diseases or conditions such as
sepsis, pneumonia, trauma, shock, and inhalation of toxic gases. Many efforts have been …