Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …

Amyotrophic lateral sclerosis is a progressive adult-onset neurodegenerative disease that
primarily affects upper and lower motor neurons, but also frontotemporal and other regions …

The first case reports of amyotrophic lateral sclerosis (ALS) date back to Charles Bell in
1824. 1 Although a variety of other clinical descriptions followed throughout the 1850s, 2–4 …

Motor neuron disorders (MND) include a group of pathologies that affect upper and/or lower
motor neurons. Among them, amyotrophic lateral sclerosis (ALS) is characterized by …

The neuropathic disorders can be confusing to a clinician first encountering them but several
key patterns of involvement can help lead to the proper diagnosis (Table 1). For a full …

Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …

Motor neuron diseases (MNDs) are a debilitating subset of diseases, which result in
progressive neuronal destruction and eventual loss of voluntary muscular function. These …

Background and objectives Primary lateral sclerosis (PLS) is a motor neuron disease
characterised by loss of the upper motor neurons. Most patients present with slowly …

We aimed to identify the genetic cause of the devastating neurodegenerative disease
amyotrophic lateral sclerosis (ALS) in a German family with two affected individuals, and to …

Despite an early understanding of amyotrophic lateral sclerosis (ALS) as a disease affecting
the motor system, including motoneurons in the motor cortex, brainstem, and spinal cord …