Substance use disorders are chronic, relapsing, and harmful conditions characterized by
executive dysfunction. While there are currently no approved pharmacotherapy options for …

Objective: To perform a systematic review of the present scientific literature on the treatment
with methadone or buprenorphine related to (1) traffic accident risk in epidemiological …

Cognitive impairment seems to be highly prevalent in patients with advanced cancer.
Modafinil, a novel vigilance and wake-promoting agent, may be an alternative treatment. We …

Objective To describe simultaneous pharmacokinetics (PK) and thermal antinociception
after intravenous (IV), intramuscular (IM) and subcutaneous (SC) buprenorphine in cats …

Aims The present study assessed the acute effects of methadone and buprenorphine on
actual on‐road driving performance and neurocognitive function. Methods Methadone (5 …

Introduction The USA is in an opioid epidemic, with an increased number of individuals
taking psychoactive drugs while executing the tasks of everyday life, including operating a …

Introduction Alcohol, tobacco, and illegal drug usage is pervasive throughout the world, and
abuse of these substances is a major contributor to the global disease burden. Many …

Aims Norway has introduced legal concentration limits in blood for 28 non-alcohol drugs in
driving under the influence cases. As of 2016 this legislation also regulates the assessment …

Pharmacokinetic/pharmacodynamic (PK/PD) modelling can be used to characterize the
relationship between dose regimen of opioids, plasma concentration and effect of opioids …

Low doses of μ-opioid receptor (MOR) agonists rapidly ameliorate symptoms in treatment-
resistant obsessive–compulsive disorder (OCD) patients (10–50% of OCD patients) …