Generic acquisition protocol for quantitative MRI of the spinal cord

J Cohen-Adad, E Alonso-Ortiz, M Abramovic… - Nature protocols, 2021 - nature.com
Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges,
including a lack of standardized imaging protocols. Here we present a prospectively …

Probing myelin content of the human brain with MRI: A review

GF Piredda, T Hilbert, JP Thiran… - Magnetic resonance in …, 2021 - Wiley Online Library
Rapid and efficient transmission of electric signals among neurons of vertebrates is ensured
by myelin‐insulating sheaths surrounding axons. Human cognition, sensation, and motor …

Validating the sensitivity of inhomogeneous magnetization transfer (ihMT) MRI to myelin with fluorescence microscopy

G Duhamel, VH Prevost, M Cayre, A Hertanu… - Neuroimage, 2019 - Elsevier
Abstract Inhomogeneous Magnetization Transfer (ihMT) is a development from the MT MRI
technique. IhMT can be considered as a dipolar order relaxation time (T 1D) weighted …

[HTML][HTML] Spinal cord imaging in amyotrophic lateral sclerosis: historical concepts—novel techniques

MM El Mendili, G Querin, P Bede, PF Pradat - Frontiers in neurology, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common adult onset motor neuron disease
with no effective disease modifying therapies at present. Spinal cord degeneration is a …

The spinal and cerebral profile of adult spinal-muscular atrophy: a multimodal imaging study

G Querin, MM El Mendili, T Lenglet, A Behin… - NeuroImage: Clinical, 2019 - Elsevier
Spinal muscular atrophy (SMA) type III and IV are autosomal recessive, slowly progressive
lower motor neuron syndromes. Nevertheless, wider cerebral involvement has been …

“Switchboard” malfunction in motor neuron diseases: Selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis

RH Chipika, E Finegan, SLH Shing, MC McKenna… - NeuroImage: Clinical, 2020 - Elsevier
The thalamus is a key cerebral hub relaying a multitude of corticoefferent and corticoafferent
connections and mediating distinct extrapyramidal, sensory, cognitive and behavioural …

The changing landscape of motor neuron disease imaging: the transition from descriptive studies to precision clinical tools

P Bede, G Querin, PF Pradat - Current opinion in neurology, 2018 - journals.lww.com
The changing landscape of motor neuron disease imaging: the... : Current Opinion in
Neurology The changing landscape of motor neuron disease imaging: the transition from …

Inhomogeneous magnetization transfer imaging: Concepts and directions for further development

DC Alsop, E Ercan, OM Girard, AL Mackay… - NMR in …, 2023 - Wiley Online Library
Off‐resonance radio frequency irradiation can induce the ordering of proton spins in the
dipolar fields of their neighbors, in molecules with restricted mobility. This dipolar order …

[HTML][HTML] Alterations in somatosensory, visual and auditory pathways in amyotrophic lateral sclerosis: an under-recognised facet of ALS

RH Chipika, G Mulkerrin, A Murad, J Lope… - Journal of integrative …, 2022 - imrpress.com
Background: While amyotrophic lateral sclerosis (ALS) is widely recognised as a multi-
network disorder with extensive frontotemporal and cerebellar involvement, sensory …

Chitotriosidase, a biomarker of amyotrophic lateral sclerosis, accentuates neurodegeneration in spinal motor neurons through neuroinflammation

AM Varghese, M Ghosh, SK Bhagat… - Journal of …, 2020 - Springer
Background Cerebrospinal fluid from amyotrophic lateral sclerosis patients (ALS-CSF)
induces neurodegenerative changes in motor neurons and gliosis in sporadic ALS models …