Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

Neurodegenerative diseases are characterized by gradually progressive, selective loss of
anatomically or physiologically related neuronal systems that produce brain damage from …

Mutations disrupting the nuclear localization of the RNA-binding protein FUS characterize a
subset of amyotrophic lateral sclerosis patients (ALS-FUS). FUS regulates nuclear RNAs …

Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor
in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which motor neurons
throughout the brain and spinal cord progressively degenerate resulting in muscle atrophy …

Spastic cerebral palsy (CP), despite the name, is not consistently identifiable by specific
brain lesions. CP animal models focus on risk factors for development of CP, yet few …

Preterm birth complications are the leading cause of child death worldwide and a top global
health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral …

Symmorphosis is a concept of economy of biological design, whereby structural properties
are matched to functional demands. According to symmorphosis, biological structures are …

The mammalian neuromuscular junction (NMJ) comprises a presynaptic terminal, a
postsynaptic receptor region on the muscle fiber (endplate), and the perisynaptic (terminal) …

The synapse is an incredibly specialized structure that allows for the coordinated
communication of information from one neuron to another. When assembled into circuits …