Alzheimer's pathogenic mechanisms and underlying sex difference

D Zhu, A Montagne, Z Zhao - Cellular and Molecular Life Sciences, 2021 - Springer
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …

[HTML][HTML] Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective

M Baumgart, HM Snyder, MC Carrillo, S Fazio… - Alzheimer's & …, 2015 - Elsevier
An estimated 47 million people worldwide are living with dementia in 2015, and this number
is projected to triple by 2050. In the absence of a disease-modifying treatment or cure …

New insights into the genetic etiology of Alzheimer's disease and related dementias

C Bellenguez, F Küçükali, IE Jansen, L Kleineidam… - Nature …, 2022 - nature.com
Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: Combined data from 13 community-based or population …

PT Nelson, C Brayne, ME Flanagan, EL Abner… - Acta …, 2022 - Springer
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …

2018 Alzheimer's disease facts and figures

Alzheimer's Association - Alzheimer's & Dementia, 2018 - Elsevier
This article describes the public health impact of Alzheimer's disease (AD), including
incidence and prevalence, mortality and morbidity, costs of care, and the overall impact on …

2016 Alzheimer's disease facts and figures

Alzheimer's Association - Alzheimer's & Dementia, 2016 - Elsevier
This report describes the public health impact of Alzheimer's disease, including incidence
and prevalence, mortality rates, costs of care, and the overall impact on caregivers and …

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

DJ Baker, RC Petersen - The Journal of clinical …, 2018 - Am Soc Clin Investig
Along with a general decline in overall health, most chronic degenerative human diseases
are inherently associated with increasing age. Age-associated cognitive impairments and …

Apolipoprotein E genotype and sex risk factors for Alzheimer disease: a meta-analysis

SC Neu, J Pa, W Kukull, D Beekly, A Kuzma… - JAMA …, 2017 - jamanetwork.com
Importance It is unclear whether female carriers of the apolipoprotein E (APOE) ε4 allele are
at greater risk of developing Alzheimer disease (AD) than men, and the sex-dependent …

Differences between women and men in incidence rates of dementia and Alzheimer's disease

CR Beam, C Kaneshiro, JY Jang… - Journal of …, 2018 - content.iospress.com
In the following brief report, we examined gender differences in incidence rates of any
dementia, Alzheimer's disease (AD) alone, and non-Alzheimer's dementia alone in 16,926 …

An overview of the role of lipofuscin in age-related neurodegeneration

A Moreno-García, A Kun, O Calero, M Medina… - Frontiers in …, 2018 - frontiersin.org
Despite aging being by far the greatest risk factor for highly prevalent neurodegenerative
disorders, the molecular underpinnings of age-related brain changes are still not well …