Long–term use of spinal opioids to treat chronic severe pain is widely established. However,
the indications, shortcomings and complications of the method have not been completely …

Objective: The objective of this study was to investigate the hypothalamicpituitary-gonadal
response to intrathecal opioids. Patients: Thirty patients receiving intrathecal morphine for …

Intrathecal delivery (IT) of opiates into the cerebrospinal fluid (CSF) for anesthesia and pain
relief has been used clinically for decades, but this relatively straightforward approach of …

Evidence-based medicine depends on the existence of controlled clinical trials that establish
the safety and efficacy of specific therapeutic techniques. Many interventions in clinical …

Opioids are a mainstay of treatment for pain worldwide. Pruritus, a common side effect of
opioids, is a patient dissatisfier that limits their use in many clinical settings. Both parenteral …

The pharmacokinetics and pharmacodynamics of ziconotide were assessed over a 48‐hour
period following intrathecal (IT) administration (1, 5, 7.5, or 10 μg) to 22 patients with chronic …

The analgesic efficacy and CSF pharmacokinetics of intrathecal morphine sulphate and
morphine-6-glucuronide (M6G) were compared in a single-blind crossover study. Lumbar …

Early Spinal Drug Delivery he demonstration by James Leonard Coming in 18851 that
cocaine delivered into the perispinal space would produce a state of hind-limb paralysis in …

BACKGROUND: Continuous intrathecal drug delivery provides new options for chronic
delivery of drugs that target the spinal cord, but therapeutic efficacy is highly variable. Using …

08. MUGABURE Page 1 55 Rev. Soc. Esp. Dolor 12: 33-45, 2005 Fisiología y farmacología
clínica de los opioides epidurales e intratecales B. Mugabure1, E. Echaniz1 y M. Marín2 …