Diffusion‐weighted imaging (DWI) is an established MRI technique that can investigate
tissue microstructure at the scale of a few micrometers. Musculoskeletal tissues typically …

Due to its exceptional sensitivity to soft tissues, MRI has been extensively utilized to assess
anatomical muscle parameters such as muscle volume and cross‐sectional area …

Background Nusinersen recently became available as the first treatment for Spinal Muscular
Atrophy (SMA) and data on its effectiveness and safety in adult SMA patients are still scarce …

Abstract 5q-associated spinal muscular atrophy (SMA) is a rare genetic disease caused by
mutations in the SMN1 gene, resulting in a loss of functional SMN protein and consecutive …

To evaluate differences in qMRI parameters of muscle diffusion tensor imaging (mDTI), fat-
fraction (FF) and water T2 time in leg muscles of calpainopathy patients (LGMD R1/D4) …

Objectives Quantitative MRI (qMRI) of muscles is a promising tool to measure disease
progression or to assess therapeutic effects in neuromuscular diseases. Longitudinal …

Genetic therapy has changed the prognosis of hereditary proximal spinal muscular atrophy,
although treatment efficacy has been variable. There is a clear need for deeper …

MRI's transverse relaxation time (T2) is sensitive to tissues' composition and pathological
state. While variations in T2 values can be used as clinical biomarkers, it is challenging to …

Background Magnetic resonance imaging (MRI) is currently explored as supplemental tool
to monitor disease progression and treatment response in various neuromuscular disorders …

Objective: To summarize applications of muscle magnetic resonance imaging (MRI) in cross-
sectional assessment and longitudinal monitoring of motor neuron diseases and evaluate …