Dihydropyrimidinones such as compound 12 exhibited high binding affinity and subtype
selectivity for the cloned human α1a receptor. Systematic modifications of 12 led to …

Introduction Silodosin determines smooth muscle relaxation in bladder and prostate tissues,
increases bladder blood flow in conditions of chronic bladder ischemia and regulates the …

KMD-3213, an α1a-adrenoceptor (AR) antagonist, is under development for the treatment of
urinary outlet obstruction in patients with benign prostatic hypertrophy. In the present study …

α1-Adrenergic receptor antagonists are commonly used to treat male lower urinary tract
symptoms and benign prostatic hyperplasia (BPH). We performed a literature search using …

PURPOSE: We evaluated the binding and functional affinity of KMD-3213 and other α1-
adrenoceptor (AR) antagonists such as prazosin or tamsulosin, to compare the tissue …

PURPOSE: To determine the mechanism of intraoperative floppy-iris syndrome (IFIS) by
examining the binding affinity of tamsulosin and silodosin to α-receptors and melanin …

Pharmacological profiles of tritiated KMD‐3213, a new antagonist of α1‐adrenoceptor (AR),
were examined in recombinant and native α1‐AR, and compared with those of prazosin (PZ) …

L-771,688 (SNAP 6383, methyl (4S)-4-(3, 4-difluorophenyl)-6-[(methyloxy) methyl]-2-oxo-3-
[({3-[4-(2-pyridinyl)-1-piperidinyl] propyl} amino) carbonyl]-1, 2, 3, 4-tetrahydro-5 …

A series of indoline and indole derivatives were designed, synthesized, and evaluated as
selective α1A-adrenergic receptor (α1A-AR) antagonists for the treatment of benign prostatic …

We report the synthesis and evaluation of novel α1a adrenoceptor subtype-selective
antagonists. Systematic modification of the lipophilic 4, 4-diphenylpiperidinyl moiety of the …