The cerebral signature for pain perception and its modulation
Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
knowledge of how pain signals are initially interpreted and subsequently transmitted and …
Pediatric chronic pain: biopsychosocial assessment and formulation
C Liossi, RF Howard - Pediatrics, 2016 - publications.aap.org
Dr Liossi conducted the initial literature review, and drafted and revised the initial
manuscript; Dr Howard further contributed to the literature review and reviewed and revised …
manuscript; Dr Howard further contributed to the literature review and reviewed and revised …
[HTML][HTML] Can sliding-window correlations reveal dynamic functional connectivity in resting-state fMRI?
During the last several years, the focus of research on resting-state functional magnetic
resonance imaging (fMRI) has shifted from the analysis of functional connectivity averaged …
resonance imaging (fMRI) has shifted from the analysis of functional connectivity averaged …
An fMRI-based neurologic signature of physical pain
Background Persistent pain is measured by means of self-report, the sole reliance on which
hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds …
hampers diagnosis and treatment. Functional magnetic resonance imaging (fMRI) holds …
Clinical biomarkers in drug discovery and development
R Frank, R Hargreaves - Nature reviews Drug discovery, 2003 - nature.com
Biomarkers enable the characterization of patient populations and quantitation of the extent
to which new drugs reach intended targets, alter proposed pathophysiological mechanisms …
to which new drugs reach intended targets, alter proposed pathophysiological mechanisms …
The downward spiral of chronic pain, prescription opioid misuse, and addiction: cognitive, affective, and neuropsychopharmacologic pathways
Prescription opioid misuse and addiction among chronic pain patients are emerging public
health concerns of considerable significance. Estimates suggest that more than 10% of …
health concerns of considerable significance. Estimates suggest that more than 10% of …
From nociception to pain perception: imaging the spinal and supraspinal pathways
Functional imaging techniques have allowed researchers to look within the brain, and
revealed the cortical representation of pain. Initial experiments, performed in the early …
revealed the cortical representation of pain. Initial experiments, performed in the early …
Variation in the μ-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection
Scientific understanding of social pain—the hurt feelings resulting from social rejection,
separation, or loss—has been facilitated by the hypothesis that such feelings arise, in part …
separation, or loss—has been facilitated by the hypothesis that such feelings arise, in part …
Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disorders
EA Mayer, BD Naliboff, ADB Craig - Gastroenterology, 2006 - gastrojournal.org
We define these as the motivations and feelings that are associated with changes in the
body's physiological condition and with the autonomic responses and behaviors that occur …
body's physiological condition and with the autonomic responses and behaviors that occur …
The importance of context: when relative relief renders pain pleasant
When moderate pain was presented in a context of intense pain, it induced a relief and
'hedonic flip'such that pain was reported as pleasant. ABSTRACT Context can influence the …
'hedonic flip'such that pain was reported as pleasant. ABSTRACT Context can influence the …