Objective The aim of this study was the comprehensive characterisation of longitudinal
clinical, electrophysiological and neuroimaging measures in type III and IV adult spinal …

Complex locomotor patterns are generated by combination of muscle synergies. How
genetic processes, early sensorimotor experiences, and the developmental dynamics of …

Since the introduction of disease modifying treatments there is an unmet need to identify
biomarkers of spinal muscular atrophy (SMA) natural history. We performed a systematic …

Imaging studies of FTD typically present group-level statistics between large cohorts of
genetically, molecularly or clinically stratified patients. Group-level statistics are …

The majority of radiology studies in neurodegenerative conditions infer group-level imaging
traits from group comparisons. While this strategy is helpful to define phenotype-specific …

Computational imaging and quantitative biomarkers offer invaluable insights in the pre-
symptomatic phase of neurodegenerative conditions several years before clinical …

Background Spinal muscular atrophy (SMA) is a genetic motor neuron disease related to
deletions in the SMN1 gene. There is mounting evidence that the disease is not restricted to …

Introduction Hereditary spastic paraplegias (HSP) include a clinically and genetically
heterogeneous group of conditions. Novel imaging modalities have been increasingly …

Background and purpose We quantified peripheral nerve lesions in adults with 5q‐linked
spinal muscular atrophy (SMA) type 3 by analysing the magnetization transfer ratio (MTR) of …

There is an ever growing literature on frontotemporal dysfunction in motor neuron diseases,
but the practical caveats of using imaging to evaluate extra-motor changes and linking …