Background Post-polio syndrome (PPS) has been traditionally considered a slowly
progressive condition that affects poliomyelitis survivors decades after their initial infection …

Objective Spinal muscular atrophy (SMA) is a neurodegenerative disorder characterized by
the degeneration of motor neurons in the spinal cord. It remains uncertain whether the …

Mutations in ASAH1 have been linked to two allegedly distinct disorders: Farber disease
(FD) and spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME). We …

Although we acknowledge the academic achievements of large descriptive studies, an
unmet priority of neuroimaging in MND is the development of robust diagnostic, prognostic …

Purpose Cervical spondylotic amyotrophy (CSA) is characterized by upper limb muscle
weakness and atrophy, without sensory deficits. The pathophysiology of CSA has been …

Spinal muscular atrophy (SMA) is a devastating genetic neuromuscular disease. Diffuse
neuropathology has been reported in SMA patients and mouse models, however, functional …

Background: The cerebellum integrates a multitude of motor and cognitive processes
through ample spinal and supratentorial projections. Despite emerging evidence of adaptive …

Objective Poliomyelitis results in changes to the anterior horn cell. The full extent of cortical
network changes in the motor physiology of polio survivors has not been established. Our …

Introduction The VAPB gene is associated with fALS (fALS 8). This disease presents a
variable phenotype and no study sought to characterize its neuroanatomical abnormalities …

Background: 5q Spinal Muscular Atrophy (SMA) is a prototypical lower motor neuron
disorder. However, the characteristic early motor impairment raises the question on the …