Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis
The diagnosis of amyotrophic lateral sclerosis can be challenging due to its heterogeneity in
clinical presentation and overlap with other neurological disorders. Diagnosis early in the …
clinical presentation and overlap with other neurological disorders. Diagnosis early in the …
Primary lateral sclerosis: a distinct entity or part of the ALS spectrum?
E Finegan, RH Chipika, SLH Shing… - … Lateral Sclerosis and …, 2019 - Taylor & Francis
Primary lateral sclerosis (PLS) has been traditionally viewed as a distinct upper motor
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …
The clinical and radiological profile of primary lateral sclerosis: a population-based study
Background Primary lateral sclerosis is a progressive upper-motor-neuron disorder
associated with markedly longer survival than ALS. In contrast to ALS, the genetic …
associated with markedly longer survival than ALS. In contrast to ALS, the genetic …
[HTML][HTML] Brainstem pathology in amyotrophic lateral sclerosis and primary lateral sclerosis: a longitudinal neuroimaging study
Background Brainstem pathology is a hallmark feature of ALS, yet most imaging studies
focus on cortical grey matter alterations and internal capsule white matter pathology …
focus on cortical grey matter alterations and internal capsule white matter pathology …
Extra-motor cerebral changes and manifestations in primary lateral sclerosis
E Finegan, SLH Shing, RH Chipika, KM Chang… - Brain imaging and …, 2021 - Springer
Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …
[HTML][HTML] Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling
Background Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …
Not a benign motor neuron disease: longitudinal imaging captures relentless motor connectome disintegration in primary lateral sclerosis
M Tahedl, EL Tan, SLH Shing… - European Journal of …, 2023 - Wiley Online Library
Background and purpose Primary lateral sclerosis (PLS) is a progressive upper motor
neuron disorder associated with considerable clinical disability. Symptoms are typically …
neuron disorder associated with considerable clinical disability. Symptoms are typically …
[HTML][HTML] Propagation patterns in motor neuron diseases: Individual and phenotype-associated disease-burden trajectories across the UMN-LMN spectrum of MNDs
Motor neuron diseases encompass a divergent group of conditions with considerable
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …
Neuroimaging in primary lateral sclerosis
Increased interest in the underlying pathogenesis of primary lateral sclerosis (PLS) and its
relationship to amyotrophic lateral sclerosis (ALS) has corresponded to a growing number of …
relationship to amyotrophic lateral sclerosis (ALS) has corresponded to a growing number of …
Imaging in amyotrophic lateral sclerosis: MRI and PET
J Kassubek, M Pagani - Current opinion in neurology, 2019 - journals.lww.com
MRI and PET studies in ALS have consistently shown patterns of functional and structural
changes considered to be the pathological signature of the disease. The constant advance …
changes considered to be the pathological signature of the disease. The constant advance …