This review provides an overview of the clinical issue of poorly controlled postoperative pain
and therapeutic approaches that may help to address this common unresolved health-care …

Physicians, policymakers, and researchers are increasingly focused on finding ways to
decrease opioid use and overdose in the United States both of which have sharply …

Overdose deaths are often viewed as the leading edge of the opioid epidemic which has
gripped the United States over the past two decades (Skolnick, 2018a). This emphasis is …

Background Fentanyl and non-pharmaceutical fentanyls (NPFs) have been responsible for
numerous outbreaks of overdoses all over the United States since the 1970s. However …

Administration of substances to laboratory animals requires careful consideration and
planning to optimize delivery of the agent to the animal while minimizing potential adverse …

Community-based opioid overdose prevention programs (OOPPs) that include the
distribution of naloxone have increased in response to alarmingly high overdose rates in …

Substance use disorders (SUDs), defined as a collection of symptoms including tolerance
and withdrawal, are chronic illnesses characterized by relapse and remission. In the United …

BACKGROUND: Opioid-related adverse events are a serious problem in hospitalized
patients. Little is known about patients who are likely to experience opioid-induced …

Opioid-induced respiratory depression is potentially life-threatening and often regarded as
the main hazard of opioid use. Main cause of death is cardiorespiratory arrest with hypoxia …

Elderly, female sex, presence of obstructive sleep apnea, chronic obstructive pulmonary
disease, cardiac disease, diabetes mellitus, hypertension, neurologic disease, renal …