Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …

Amyotrophic lateral sclerosis is a relentlessly progressive multi-system condition. The
clinical picture is dominated by upper and lower motor neuron degeneration, but extra-motor …

Motor neuron diseases encompass a divergent group of conditions with considerable
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …

An important part of the central nervous system (CNS), the cerebellum is involved in motor
control, learning, reflex adaptation, and cognition. Diminished cerebellar function results in …

Spinalmuscular atrophy (SMA) is a neuromuscular disease that affects as many as 1 in 6000
individuals at birth, making it the leading genetic cause of infant mortality. A growing number …

Since the introduction of disease modifying treatments there is an unmet need to identify
biomarkers of spinal muscular atrophy (SMA) natural history. We performed a systematic …

On November 19th− 21st, 2021, a group of 23 scientists and clinicians, along with two
patient advocates, one individual with SMA and three pharma representatives from 11 …

Background: 5q Spinal Muscular Atrophy (SMA) is a prototypical lower motor neuron
disorder. However, the characteristic early motor impairment raises the question on the …

There has recently been some concern on possible cognitive impairment in patients with
Spinal Muscular Atrophy (SMA). The aim of this study was to assess cognitive profiles in type …

Methods Individual‐level gray matter (GM) networks were constructed by estimating the
interregional similarity of GM volume distribution using both Kullback–Leibler divergence …