The blood-brain barrier (BBB) permeability to morphine and morphine-6-glucuronide (M6G)
is measured under identical conditions using an intravenous injection method in the rat and …

This study was done to find out how morphine 6‐beta‐d‐glucuronide (M6G) induces more
potent central analgesia than morphine, despite its poor blood–brain barrier (BBB) …

Although the specimen of choice in the US drug testing industry is urine, and serum in
clinical medicine, interest has recently grown in the use of other matrices as drug testing …

Abstract Cycloeucalenone (1) and 24-oxo-31-norcycloartanone (2) obtained from Solanum
cernuum Vell. were assayed to explore their pharmacologic roles. Previous studies showed …

Aim To compare the time course of morphine and metabolite concentrations in serum and
cerebrospinal fluid (CSF) after intravenous and intramuscular administration after surgery …

Background. The analgesic effects of morphine are delayed relative to its concentration in
blood. The rate of equilibration of morphine between blood and brain may contribute to this …

The European Association for Palliative Care guidelines for treatment of cancer pain
recommend a double dose (DD) of immediate-release morphine at bedtime instead of single …

Background and purpose: At present there are few data regarding the rate and extent of
brain–blood partitioning of the opioid active metabolite of morphine, morphine‐6 …

Yannick, tu m'as accueilli dans ton équipe, tu m'as fait confiance, tu m'as laissé une liberté
scientifique sans bornes et j'ai eu l'occasion de m'essayer à un panel de techniques …

Les effets de la morphine sont influencés par le sexe. Chez le rongeur, son métabolisme
implique sa glucuronidation en morphine-3-glucuronide (M3G). La M3G provoque une …