Assembly of the cardiac pacemaking complex: electrogenic principles of sinoatrial node morphogenesis
M Easterling, S Rossi, AJ Mazzella… - Journal of Cardiovascular …, 2021 - mdpi.com
Cardiac pacemaker cells located in the sinoatrial node initiate the electrical impulses that
drive rhythmic contraction of the heart. The sinoatrial node accounts for only a small …
drive rhythmic contraction of the heart. The sinoatrial node accounts for only a small …
[HTML][HTML] Functional heterogeneity of cell populations increases robustness of pacemaker function in a numerical model of the sinoatrial node tissue
AV Maltsev, MD Stern, EG Lakatta… - Frontiers in physiology, 2022 - frontiersin.org
Each heartbeat is initiated by specialized pacemaker cells operating within the sinoatrial
node (SAN). While individual cells within SAN tissue exhibit substantial heterogeneity of …
node (SAN). While individual cells within SAN tissue exhibit substantial heterogeneity of …
[HTML][HTML] The cardiac pacemaker story—fundamental role of the Na+/Ca2+ exchanger in spontaneous automaticity
The electrophysiological mechanism of the sinus node automaticity was previously
considered exclusively regulated by the so-called “funny current”. However, parallel …
considered exclusively regulated by the so-called “funny current”. However, parallel …
[HTML][HTML] Cardiac pacemaker dysfunction arising from different studies of ion channel remodeling in the aging rat heart
The function of the sinoatrial node (SAN), the pacemaker of the heart, declines with age,
resulting in increased incidence of sinoatrial node dysfunction (SND) in older adults. The …
resulting in increased incidence of sinoatrial node dysfunction (SND) in older adults. The …
Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling
Schizophrenia patients have an increased risk of cardiac dysfunction. A possible factor
underlying this comorbidity are the common variants in the large set of genes that have …
underlying this comorbidity are the common variants in the large set of genes that have …
Pacemaking function of two simplified cell models
Simplified nonlinear models of biological cells are widely used in computational
electrophysiology. The models reproduce qualitatively many of the characteristics of various …
electrophysiology. The models reproduce qualitatively many of the characteristics of various …
Circadian regulation of sinoatrial nodal cell pacemaking function: Dissecting the roles of autonomic control, body temperature, and local circadian rhythmicity
Strong circadian (~ 24h) rhythms in heart rate (HR) are critical for flexible regulation of
cardiac pacemaking function throughout the day. While this circadian flexibility in HR is …
cardiac pacemaking function throughout the day. While this circadian flexibility in HR is …
The virtual sinoatrial node: What did computational models tell us about cardiac pacemaking?
E Ricci, C Bartolucci, S Severi - Progress in Biophysics and Molecular …, 2023 - Elsevier
Since its discovery, the sinoatrial node (SAN) has represented a fascinating and complex
matter of research. Despite over a century of discoveries, a full comprehension of …
matter of research. Despite over a century of discoveries, a full comprehension of …
Parallel simulation of the synchronization of heterogeneous cells in the sinoatrial node
A Nicolás Mata, G Román Alonso… - Concurrency and …, 2020 - Wiley Online Library
The cells of the sinoatrial node (SAN) are self‐excitable entities that show a coupled
electrical pattern that consists of the synchronized activation of action potentials that …
electrical pattern that consists of the synchronized activation of action potentials that …