Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …

Mechanical hallmarks of fibrotic microenvironments are both outcomes and causes of
fibrosis progression. Understanding how cells sense and transmit mechanical cues in the …

Myocardial fibrosis is a remodeling process of the extracellular matrix (ECM) following
cardiac stress.“Replacement fibrosis” is a term used to describe wound healing in the acute …

Excessive cardiac fibrosis impairs cardiac repair after myocardial infarction (MI). In this work,
an injectable composite hydrogel integrating natural biomaterials, exosomes, and bioactive …

Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …

Accumulating evidence indicates that two major proteins are responsible for the structural
coherence of bounding cardiomyocytes. These biomolecules are known as myocardial …

Background: The prognostic significance of focal and diffuse myocardial fibrosis in patients
with cardiovascular risk factors is unclear. Methods: REMODEL (Response of the …

Cardiac remodelling refers to changes in left ventricular structure and function over time,
with a progressive deterioration that may lead to heart failure (HF) development (adverse …

Hypertensive heart disease (HHD) is currently the second leading cause of heart failure. The
prevalence of HHD and its associated risk of heart failure have increased despite substantial …