Although a contribution of sex in opioid efficacy has garnered much attention, the
confirmation and direction of any such difference remain elusive. We performed a systematic …

New effective analgesics are needed for the treatment of pain. Buprenorphine, a partial mu-
opioid agonist which has been in clinical use for over 25 years, has been found to be …

Opium, derived from the Greek word for “juice,” is extracted from the latex sap of the opium
poppy (Papaverum somniferum). The juice of the poppy is the source of some 20 different …

The sublingual combination tablet formulation of buprenorphine and naloxone at a fixed
dose ratio of 4: 1 has been shown to be as effective as the tablet formulation containing only …

This paper reports a series of 20 fatalities involving a high-dose, sublingual buprenorphine
(BUP) formulation recently marketed in France for the substitutive therapy of opiate addicts …

Aims. Buprenorphine at high dosage became available in 1996 for substitution treatment in
France. This drug is considered particulary safe and has become widely available in general …

Opioids are widely used as the pain reliever and also notorious for being addictive drugs.
Sex differences in the opioid analgesia and addiction have been reported and investigated …

Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the
pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory …

The objective of this investigation was to characterize the pharmacokinetic/
pharmacodynamic correlation of buprenorphine and fentanyl for the antinociceptive effect in …

Buprenorphine is commonly used to control postoperative pain in rodents. Short-acting
formulations of buprenorphine (bup-HCl) require frequent handling and restraint of animals …