The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …

The incidence of neurodegenerative diseases has shown an increasing trend. These
conditions typically cause progressive functional disability. Identification of robust …

In brain regions containing crossing fibre bundles, voxel-average diffusion MRI measures
such as fractional anisotropy (FA) are difficult to interpret, and lack within-voxel single fibre …

Objective Damage to the cerebral tissue structural connectivity associated with amyotrophic
lateral sclerosis (ALS), which extends beyond the motor pathways, can be visualised by …

Disruptions to genes linked to RNA processing and homeostasis are implicated in the
pathogenesis of two pathologically related but clinically heterogeneous neurodegenerative …

Importance Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder primarily
affecting the motor system, with extramotor involvement to a variable extent. Biomarkers for …

Heavy metals, including lead (Pb), cadmium (Cd), arsenic (As), cobalt (Co), copper (Cu),
manganese (Mn), zinc (Zn), and others, have a significant impact on the development and …

Abstract Purpose of Review: This review describes the most common motor neuron disease,
ALS. It discusses the diagnosis and evaluation of ALS and the current understanding of its …

Background While neuroimaging in ALS has gained unprecedented momentum in recent
years, little progress has been made in the development of viable diagnostic, prognostic and …

The study of amyotrophic lateral sclerosis (ALS) and potential interventions would be
facilitated if motor axon degeneration could be more readily visualized. Here we …