Introduction Within the core neuroimaging signature of amyotrophic lateral sclerosis (ALS),
the corpus callosum (CC) is increasingly recognized as a consistent feature. The aim of this …

BACKGROUND AND PURPOSE: Amyotrophic lateral sclerosis is a progressive motor
neuron disorder that involves degeneration of both upper and lower motor neurons. In …

Amyotrophic lateral sclerosis is a neurodegenerative disease characterized by a preferential
involvement of both upper and lower motor neurons. Evidence from neuroimaging and post …

The main objective of this study was to utilize high field (7T) in vivo proton magnetic
resonance imaging to increase the ability to detect metabolite changes in people with ALS …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder and is characterized by
degeneration and axon loss from the upper motor neuron, that descends from the lower …

At present, limited biomarkers exist to reliably understand, diagnose, and monitor the
progression of amyotrophic lateral sclerosis (ALS), a fatal neurological disease …

Mitochondria play an essential role in maintaining energy homeostasis and cellular survival.
In the brain, higher ATP production is required by mature neurons for communication. Most …

Background: Oxidative stress and protein aggregation are key mechanisms in amyotrophic
lateral sclerosis (ALS) disease. Reduced glutathione (GSH) is the most important …

To determine longitudinal rates of cortical atrophy in classical Amyotrophic lateral sclerosis
(ALS) and ALS variants. Rates of cortical thinning were determined between 2 scans, 3–15 …

Abstract [18F] AV-1451 (aka 18F-Flortaucipir,[18F] T807) was developed for positron-
emission tomography (PET) imaging of paired helical filaments of hyperphosphorylated tau …