Despite proven clinical utility, buprenorphine has not been used widely for the treatment of
chronic pain. Questions about “ceiling effect” or bell-shaped curve observed for analgesia in …

The buprenorphine receptor binding profile is unique in that it binds to all three major opioid
receptors (mu, kappa, delta), and also binds to the orphan-like receptor, the receptor for …

Buprenorphine (BUP) is an oripavine analgesic that is beneficial in the maintenance
treatment of opiate-dependent individuals. Although BUP has been studied extensively …

Opioids evoke analgesia through activation of opioid receptors (predominantly the μ opioid
receptor) in the central nervous system. Opioid receptors are abundant in multiple regions of …

New effective analgesics are needed for the treatment of pain. Buprenorphine, a partial mu-
opioid agonist which has been in clinical use for over 25 years, has been found to be …

Background: Opioid use in patients with renal impairment can lead to increased adverse
effects. Opioids differ in their effect in renal impairment in both efficacy and tolerability. This …

Buprenorphine is an opioid that has a complex and unique pharmacology which provides
some advantages over other potent mu agonists. We review 12 reasons for considering …

The traditional view of opioids held that the individual opioid agonists shared the same
mechanism of action, differing only in their potency and pharmacokinetic properties …

The unique pharmacology of buprenorphine at the mu-opioid receptor (ie high affinity, low
intrinsic activity and slow dissociation) results in buprenorphine having:(1) a good safety …

The sublingual combination tablet formulation of buprenorphine and naloxone at a fixed
dose ratio of 4: 1 has been shown to be as effective as the tablet formulation containing only …