Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca 2+ …

The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

There is currently increased interest in the use of the antimalarial drugs chloroquine and
hydroxychloroquine for the treatment of other diseases, including cancer and viral infections …

Relevant, predictive normal, or disease model systems are of vital importance for drug
development. The difference between nonhuman models and humans could contribute to …

Calcium is a highly positively charged ionic species. It regulates all cell types' functions and
is an important second messenger that controls and triggers several mechanisms, including …

The postnatal mammalian heart undergoes remarkable developmental changes, which are
stimulated by the transition from the intrauterine to extrauterine environment. With birth …

Discovered some 40 years ago, the I f current has since been known as the “pacemaker”
current due to its role in the initiation and modulation of the heartbeat and of neuronal …

This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …

Background Despite the many studies carried out over the past 40 years, the contribution of
the HCN4 encoded hyperpolarization-activated 'funny'current (I f) to pacemaker activity in …