For the optimization of dosing regimens of anti-infective agents, it is imperative to have a
good understanding of pharmacokinetics (PK) and pharmacodynamics (PD). Whenever …

The aim of this current review is to summarize the present status of pharmacokinetics in
Drug Discovery. The review is structured into four sections. The first section is a general …

Background Enhanced methods of drug monitoring are required to support the
individualisation of antibiotic dosing. We report the first-in-human evaluation of real-time …

Introduction Investigating the transportation of a drug molecule through various layers of skin
and determining the amount of drug retention in skin layers is of prime importance in …

An important feature of mechanism-based pharmacokinetic/pharmacodynamic (PK/PD)
models is the identification of drug-and system-specific factors that determine the intensity …

Contemporary models in the field of pharmacokinetic–pharmacodynamic (PK–PD) modeling
often incorporate the fundamental principles of capacity limitation and operation of turnover …

We provide an overview of the available information on the distribution of
chemotherapeutics in human tumors, highlighting the progress made to assess the …

Drug discovery and development involves a complex iterative process of new molecules
synthesis, formulations, and in vitro analysis, followed by biochemical and cellular assays …

Skin microdialysis (SMD) is a versatile sampling technique that can be used to recover
soluble endogenous and exogenous molecules from the extracellular compartment of …

Nonclinical studies are fundamental for the development of inhaled drugs, as for any drug
product, and for successful translation to clinical practice. They include in silico, in vitro, ex …