The development of new possible treatments for C9orf72-related ALS and the possibility of
early identification of subjects genetically at risk of developing the disease is creating a …

Primary lateral sclerosis (PLS) is a neurodegenerative disorder of the adult motor system.
Characterised by a slowly progressive upper motor neuron syndrome, the diagnosis is …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have a strong
clinical, genetic and pathological overlap. This review focuses on the current understanding …

Motor neuron diseases encompass a divergent group of conditions with considerable
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …

Astrocytes are major contributors of motor neuron (MN) degeneration in amyotrophic lateral
sclerosis (ALS). We investigated whether regional and cell maturation differences influence …

Although we acknowledge the academic achievements of large descriptive studies, an
unmet priority of neuroimaging in MND is the development of robust diagnostic, prognostic …

Biomarkers in amyotrophic lateral sclerosis: a review of new... : Current Opinion in
Neurology Biomarkers in amyotrophic lateral sclerosis: a review of new developments …

While C9orf72-specific imaging signatures have been proposed by both ALS and FTD
research groups and considerable presymptomatic alterations have also been confirmed in …

Objective Spinal cord degeneration is a hallmark of amyotrophic lateral sclerosis. The
assessment of gray matter and white matter cervical spinal cord atrophy across clinical …

Purpose To study the relative contributions of brain and upper cervical spinal cord
compartmental atrophy to disease aggressiveness in amyotrophic lateral sclerosis (ALS) …