Since its introduction mass spectrometry imaging (MSI) has proven to be a powerful tool for
the localization of molecules in biological tissues. In drug discovery and development …

Our understanding of drug tissue distribution impacts a number of areas in drug
development, including: pharmacology, pharmacokinetics, safety, drug–drug interactions …

Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …

During the last decades, imaging mass spectrometry has gained significant relevance in
biomedical research. Recent advances in imaging mass spectrometry have paved the way …

Understanding drug fingerprints in complex biological samples is essential for the
development of a drug. Hyperspectral coherent anti-Stokes Raman scattering (HS-CARS) …

A high-throughput method for rapid screening of in vitro drug− brain homogenate binding is
presented. The method is based on a straightforward sample pooling approach combining …

Claims for the potential health benefits of oleocanthal (OLC), a dietary phenolic compound
found in olive oil, are based mainly on in vitro studies. Little is known about the tissue …

In pharmaceutical research, understanding the biodistribution, accumulation and
metabolism of drugs in tissue plays a key role during drug discovery and development. In …

Drug discovery and development involves a complex iterative process of new molecules
synthesis, formulations, and in vitro analysis, followed by biochemical and cellular assays …

Mass spectrometry imaging (MSI) is a rapidly evolving technology that yields qualitative and
quantitative distribution maps of small pharmaceutical-active molecules and their …