Administration of anesthetic agents fundamentally shifts the responsibility for maintenance of
homeostasis from the patient and their intrinsic physiological regulatory mechanisms to the …

Cerebral blood flow (CBF) is regulated by vasomotor, chemical, metabolic, and neurogenic
mechanisms. Even though the innervation of cerebral arteries is quite extensively described …

Cerebral blood flow (CBF) is rigorously regulated by various powerful mechanisms to
safeguard the match between cerebral metabolic demand and supply. The question of how …

Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity,
and other baseline physiologies and eventually modifies the neurovascular coupling …

Solid experimental evidence supports neuroprotection by anesthetic agents. It is too early to
recommend any specific agent for clinical use as a neuroprotectant, however. Further study …

The brain is a very complex organ which needs a continuous delivery of oxygen and
nutrients. To sustain consciousness, satisfactory perfusion and adequate oxygen delivery is …

Background Reductions in cerebral metabolic rate may increase the brain's tolerance of
ischemia. However, outcome studies suggest that reductions in cerebral metabolic rate …

Current neurocritical care management strategies are focused on the prevention and
limitation of secondary brain injury where neuronal insult continues to evolve during the …

BASED on a prospective evaluation of 1,178 consecutive adult patients undergoing on-
pump cardiac surgery, in this issue of ANESTHESIOLOGY, Heringlake et al. present …

Background Barbiturates have previously been demonstrated to reduce focal cerebral
ischemic brain damage. However, the dose of drug required to elicit maximal …