Magnetic resonance spectroscopy (MRS) has contributed important academic insights in
motor neuron diseases (MNDs), particularly in amyotrophic lateral sclerosis (ALS). Over the …

It is agreed that conventional magnetic resonance imaging (MRI) of the brain and spine is
one of the core elements in the differential diagnostic work up of patients with clinical signs …

Although we acknowledge the academic achievements of large descriptive studies, an
unmet priority of neuroimaging in MND is the development of robust diagnostic, prognostic …

Objectives The lack of systematic evidence on neuroimaging findings in motor neuron
diseases (MND) hampers the diagnostic utility of magnetic resonance imaging (MRI). Thus …

Diagnosis, stratification and monitoring of disease progression in amyotrophic lateral
sclerosis currently rely on clinical history and examination. The phenotypic heterogeneity of …

Proton magnetic resonance spectroscopy (MRS) provides a means of measuring cerebral
metabolites relevant to neurodegeneration in vivo. In amyotrophic lateral sclerosis (ALS) …

Several neuroimaging modalities have been used with varying success to aid the clinical
process of establishing the diagnosis of amyotrophic lateral sclerosis (ALS). By …

The changing landscape of motor neuron disease imaging: the... : Current Opinion in
Neurology The changing landscape of motor neuron disease imaging: the transition from …

Previous MRI and proton spectroscopy (1 H-MRS) studies have revealed impaired neuronal
integrity and altered neurometabolite concentrations in the motor cortex of patients with …

The last 30 years have seen a major advance in the understanding of the clinical and
pathological heterogeneity of amyotrophic lateral sclerosis (ALS), and its overlap with …