The Hedgehog (HH) signalling pathway is one of the major pathways controlling cell
differentiation and proliferation during human development. This pathway is complex, with …

Holoprosencephaly (HPE) is a malformation sequence where the cerebral hemispheres fail
to separate into distinct left and right halves. It can be associated with midline structural …

Sonic hedgehog (Shh) is a morphogen that is crucial for normal development of a variety of
organ systems, including the brain and spinal cord, the eye, craniofacial structures, and the …

Mutations of the developmental gene Sonic hedgehog (SHH) and alterations of SHH
signaling have been associated with holoprosencephaly (HPE), a rare disorder …

Mutations in SHH and several other genes encoding components of the Hedgehog
signaling pathway have been associated with holoprosencephaly syndromes, with …

Holoprosencephaly (HPE), the most common developmental defect of the forebrain and the
face, is genetically heterogeneous. One of the genes involved, Sonic hedgehog (SHH), on …

Holoprosencephaly (HPE) is the most commonly occurring congenital structural forebrain
anomaly in humans. HPE is associated with mental retardation and craniofacial …

The hedgehog (Hh) signaling cascade is crucial for the correct development and patterning
of various vertebrate tissues and organs, including the brain and spinal cord, eye …

Mutations in the human sonic hedgehog gene (SHH) are the most frequent cause of
autosomal dominant inherited holoprosencephaly (HPE), a complex brain malformation …

Sonic hedgehog (SHH) plays an important instructional role in vertebrate development, as
exemplified by the numerous developmental disorders that occur when the SHH pathway is …