Driven to decay: excitability and synaptic abnormalities in amyotrophic lateral sclerosis

MJ Fogarty - Brain research bulletin, 2018 - Elsevier
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease and is
clinically characterised by the death of corticospinal motor neurons (CSMNs), spinal and …

[HTML][HTML] Motor neuron susceptibility in ALS/FTD

AMG Ragagnin, S Shadfar, M Vidal… - Frontiers in …, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord …

Molecular biology of amyotrophic lateral sclerosis: insights from genetics

P Pasinelli, RH Brown - Nature Reviews Neuroscience, 2006 - nature.com
Amyotrophic lateral sclerosis (ALS) is a paralytic disorder caused by motor neuron
degeneration. Mutations in more than 50 human genes cause diverse types of motor neuron …

[HTML][HTML] Synaptic failure: focus in an integrative view of ALS

C Casas, R Manzano, R Vaz, R Osta, D Brites - Brain plasticity, 2016 - content.iospress.com
From early description by Charcot, the classification of the Amyotrophic Lateral Sclerosis
(ALS) is evolving from a subtype of Motor Neuron (MN) Disease to be considered rather a …

[PDF][PDF] Advances and challenges in understanding the multifaceted pathogenesis of amyotrophic lateral sclerosis

F Laferriere, M Polymenidou - Swiss medical weekly, 2015 - hal.science
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease, which
primarily affects motor neurons leading to progressive paralysis and death within a few …

The neurobiology of amyotrophic lateral sclerosis

A Bento‐Abreu, P Van Damme… - European Journal of …, 2010 - Wiley Online Library
Amyotrophic lateral sclerosis is a degenerative disease affecting the motor neurons. In spite
of our growing insights into its biology, it remains a lethal condition. The identification of the …

Amyotrophic lateral sclerosis

O Hardiman, A Al-Chalabi, A Chio, EM Corr… - Nature reviews Disease …, 2017 - nature.com
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is characterized
by the degeneration of both upper and lower motor neurons, which leads to muscle …

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

L Ferraiuolo, J Kirby, AJ Grierson, M Sendtner… - Nature Reviews …, 2011 - nature.com
Amyotrophic lateral sclerosis (ALS) is a genetically diverse disease. At least 15 ALS-
associated gene loci have so far been identified, and the causative gene is known in …

Amyotrophic lateral sclerosis: update and new developments

AJ Pratt, ED Getzoff, JJP Perry - Degenerative neurological and …, 2012 - Taylor & Francis
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease. It is
typically characterized by adult-onset degeneration of the upper and lower motor neurons …

New therapeutic targets for amyotrophic lateral sclerosis

M Kuzma-Kozakiewicz, H Kwiecinski - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
disorders, affecting approximately half a million people worldwide. Currently there is no cure …