The pharmacokinetics and time course of blood–brain equilibration of buprenorphine (BUP)
and norbuprenorphine (norBUP) in sheep were characterized. Sheep were administered …

Buprenorphine is a potent partial-opioid agonist that is used as an analgesic in animals
and humans to ameliorate moderate to severe pain and in the treatment of opiate addiction …

The purpose of this project was to characterize the dose-dependent pharmacokinetics of
buprenorphine (BN) and norbuprenorphine (NBN), the primary metabolite, after intravenous …

Deaths have been reported among heroin addicts related to combined buprenorphine and
flunitrazepam use. The aim of this study was to determine the existence of a drug–drug …

INTRODUCTION: A specific, accurate, and reproducible liquid chromatography–mass
spectrometric (LC/MS) method was developed and validated that allows simultaneous …

The purpose of this study was to evaluate plasma concentrations and pharmacokinetic
parameters of buprenorphine in dogs following intravenous (IV) administration of clinical …

A gas chromatography tandem mass spectrometry method for quantification of
buprenorphine (BUP) and norbuprenorphine (NBUP) in brain and plasma samples from …

The relationships between plasma or brain concentrations and analgesic effects of both
buprenorphine(BN) and an active metabolite, norbuprenorphine(NBN), were investigated in …

This study reports the pharmacokinetics of buprenorphine in conscious rhesus macaques (M
acaca mulatta) after intravenous (iv) and intramuscular (im) administration. Four healthy …

The main objective of the present study was to characterize the pharmacokinetic/
pharmacodynamic (PK/PD) relationship of the effects of buprenorphine on cognitive …