To understand and exploit centrally acting drugs requires reliable measures of their time
course of action in the human brain. Functional magnetic resonance imaging (fMRI) is able …

Wepresent a method for investigating the dynamic pharmacological modulation of pain-
related brain activity, measured by BOLD-contrast fMRI. Noxious thermal stimulation was …

μ-Opioid receptor agonists are widely used within the contemporary treatment of pain, but
abrupt opioid suspension, even after short-term infusion, can paradoxically increase the …

Many pharmacological stimuli influence multiple neurotransmitter systems in the brain, and
the dynamics of the functional brain response can vary regionally. In this study, the temporal …

Background Previous imaging studies have demonstrated a number of cortical and
subcortical brain structures to be activated during noxious stimulation and infusion of …

Background The current study investigated dose-dependent effects of the mu-selective
agonist remifentanil on regional cerebral blood flow (rCBF) in volunteers using positron …

Functional magnetic resonance imaging has been widely used to study brain activation
induced either by specific sensory stimulation or motor or cognitive task performance. We …

Opioids alter resting state brain oscillations by multiple and complex factors, which are still to
be elucidated. To increase our knowledge, multi‐channel electroencephalography (EEG) …

The aims of this study were to assess the effects of a μ-opioid antagonist, naloxone, on
endogenous opioid systems and to evaluate the effect of naloxone on the CNS response to …

Chronic pain is a major problem for the individual and for society. Despite a range of drugs
being available to treat chronic pain, only inadequate pain relief can be achieved for many …