Background: Opioid use in patients with renal impairment can lead to increased adverse
effects. Opioids differ in their effect in renal impairment in both efficacy and tolerability. This …

Purpose Opioids are recommended for moderate to severe cancer pain; however, in
patients with cancer, impaired renal function can affect opioid metabolism. The aim of this …

The aim of this systematic review was to evaluate the evidence that oral morphine can be
recommended as the first choice opioid in the treatment of moderate to severe cancer pain …

The numbers of patients dying with end-stage renal disease (ESRD), particularly those
managed conservatively (without dialysis) or withdrawing from dialysis is increasing rapidly …

The World Health Organization (WHO) guidelines for the treatment of cancer pain
recommend nonopioid analgesics as first-line therapy, so-called “weak” analgesics …

Here we provide the updated version of the guidelines of the European Association for
Palliative Care (EAPC) on the use of opioids for the treatment of cancer pain. The update …

Side effects can limit opioid dosage and reduce quality of life. The purpose of this systematic
review was to assess the management of opioid side effects in the context of cancer pain …

A difficult decision for physicians who treat patients with chronic pain not associated with
terminal disease is whether and how to prescribe opioid therapy, which can relieve pain and …

PURPOSE To provide guidance on the use of opioids to manage pain from cancer or cancer
treatment in adults. METHODS A systematic review of the literature identified systematic …

Successful pain management with opioids requires that adequate analgesia be achieved
without excessive adverse effects. By these criteria, a substantial minority of patients treated …