Amyotrophic lateral sclerosis (ALS) is associated with considerable clinical heterogeneity
spanning from diverse disability profiles, differences in UMN/LMN involvement, divergent …

Objective The purpose of this study was to identify subtypes of amyotrophic lateral sclerosis
(ALS) by comparing patterns of neurodegeneration using brain magnetic resonance …

BACKGROUND AND PURPOSE: The previous studies described phenotype-associated
imaging findings in amyotrophic lateral sclerosis (ALS) with a prior categorization of patients …

Background: Oxidative stress and protein aggregation are key mechanisms in amyotrophic
lateral sclerosis (ALS) disease. Reduced glutathione (GSH) is the most important …

Background Despite significant advances in quantitative neuroimaging, the diagnosis of
ALS remains clinical and MRI-based biomarkers are not currently used to aid the diagnosis …

A large multiparametric MRI study has been undertaken to evaluate anatomical patterns of
basal ganglia, white matter and cortical grey matter involvement in ALS. Unaffected brain …

The description of group-level, genotype-and phenotype-associated imaging traits is
academically important, but the practical demands of clinical neurology centre on the …

Objective To assess the determinants of amyotrophic lateral sclerosis (ALS) phenotypes in a
population-based cohort. Methods The study population included 2,839 patients with ALS …

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is an incurable
neurodegenerative condition, characterized by the loss of upper and lower motor neurons. It …

Background While neuroimaging in ALS has gained unprecedented momentum in recent
years, little progress has been made in the development of viable diagnostic, prognostic and …