Ligand binding strategies of human serum albumin: how can the cargo be utilized?

A Varshney, P Sen, E Ahmad, M Rehan… - Chirality: The …, 2010 - Wiley Online Library
Human serum albumin (HSA), being the most abundant carrier protein in blood and a
modern day clinical tool for drug delivery, attracts high attention among biologists. Hence, its …

Stereoselective binding of human serum albumin

VTG Chuang, M Otagiri - Chirality: The Pharmacological …, 2006 - Wiley Online Library
Stereoselectivity in binding can have a significant effect on the drug disposition such as first‐
pass metabolism, metabolic clearance, renal clearance, and protein and tissue binding …

[HTML][HTML] Interactive association of drugs binding to human serum albumin

F Yang, Y Zhang, H Liang - International journal of molecular sciences, 2014 - mdpi.com
Human serum albumin (HSA) is an abundant plasma protein, which attracts great interest in
the pharmaceutical industry since it can bind a remarkable variety of drugs impacting their …

Structural basis of drug recognition by human serum albumin

L Leboffe, A di Masi, F Polticelli… - Current medicinal …, 2020 - ingentaconnect.com
Background: Human serum albumin (HSA), the most abundant protein in plasma, is a
monomeric multi-domain macromolecule with at least nine binding sites for endogenous …

Structure, enzymatic activities, glycation and therapeutic potential of human serum albumin: A natural cargo

G Rabbani, SN Ahn - International journal of biological macromolecules, 2019 - Elsevier
Human serum albumin (HSA) is an opulent, non-glycosylated, most versatile carrier protein
in plasma possessing multiple functions. HSA has the ability to interact with a variety of …

Drug binding to human serum albumin: Abridged review of results obtained with high‐performance liquid chromatography and circular dichroism

GA Ascoli, E Domenici… - … , Biological, and Chemical …, 2006 - Wiley Online Library
The drug binding to plasma and tissue proteins are fundamental factors in determining the
overall pharmacological activity of a drug. Human serum albumin (HSA), together with α1 …

Simple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapy

Z Liu, X Chen - Chemical Society Reviews, 2016 - pubs.rsc.org
Albumin is the most abundant circulating protein in plasma and has recently emerged as a
versatile protein carrier for drug targeting and for improving the pharmacokinetic profile of …

Serum albumin: Clinical significance of drug binding and development as drug delivery vehicle

S Tayyab, SR Feroz - Advances in protein chemistry and structural biology, 2021 - Elsevier
Human serum albumin, the primary transport and reservoir protein in the human circulatory
system, interacts with numerous endogenous and exogenous ligands of varying structural …

The extraordinary ligand binding properties of human serum albumin

M Fasano, S Curry, E Terreno, M Galliano, G Fanali… - IUBMB …, 2005 - Wiley Online Library
Human serum albumin (HSA), the most prominent protein in plasma, binds different classes
of ligands at multiple sites. HSA provides a depot for many compounds, affects …

Reversible and covalent binding of drugs to human serum albumin: methodological approaches and physiological relevance

C Bertucci, E Domenici - Current medicinal chemistry, 2002 - ingentaconnect.com
Human serum albumin (HSA) plays a fundamental role in the transport of drugs, metabolites,
and endogenous ligands. Binding to HSA controls the free, active concentration of a drug …