The innate immune regulator STING is a critical sensor of self-and pathogen-derived DNA.
DNA sensing by STING leads to the induction of type-I interferons (IFN-I) and other …

Patients with advanced stage cancers frequently suffer from severe pain as a result of bone
metastasis and bone destruction, for which there is no efficacious treatment. Here, using …

The innate immune system is critical for the early detection of invading pathogens and for
initiating cellular host defence countermeasures, which include the production of type I …

Aberrant activation of innate immune pathways is associated with a variety of diseases.
Progress in understanding the molecular mechanisms of innate immune pathways has led …

Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress
signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS …

Nucleic acids from bacteria or viruses induce potent immune responses in infected cells,,–.
The detection of pathogen-derived nucleic acids is a central strategy by which the host …

The innate immune system detects infection by using germline-encoded receptors that are
specific for conserved microbial molecules. The recognition of microbial ligands leads to the …

Spontaneous T cell responses against tumors occur frequently and have prognostic value in
patients. The mechanism of innate immune sensing of immunogenic tumors leading to …

The rapid detection of microbial agents is essential for the effective initiation of host defence
mechanisms against infection. Understanding how cells detect cytosolic DNA to trigger …

Innate immune response acts as the first line of host defense against damage and is initiated
following the recognition of pathogen-associated molecular patterns (PAMPs). For double …