Propagation patterns in motor neuron diseases: Individual and phenotype-associated disease-burden trajectories across the UMN-LMN spectrum of MNDs
Motor neuron diseases encompass a divergent group of conditions with considerable
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …
differences in clinical manifestations, survival, and genetic vulnerability. One of the key …
Microstructural changes across different clinical milestones of disease in amyotrophic lateral sclerosis
F Trojsi, G Caiazzo, D Corbo, G Piccirillo, V Cristillo… - PloS one, 2015 - journals.plos.org
Neurodegenerative process in amyotrophic lateral sclerosis (ALS) has been proven to
involve several cortical and subcortical brain regions within and beyond motor areas …
involve several cortical and subcortical brain regions within and beyond motor areas …
ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration
JM Ravits, AR La Spada - Neurology, 2009 - AAN Enterprises
Heterogeneity of motor phenotypes is a clinically well-recognized fundamental aspect of
amyotrophic lateral sclerosis (ALS) and is determined by variability of 3 independent primary …
amyotrophic lateral sclerosis (ALS) and is determined by variability of 3 independent primary …
Characteristic increases in EEG connectivity correlate with changes of structural MRI in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a terminal progressive adult-onset neurodegeneration
of the motor system. Although originally considered a pure motor degeneration, there is …
of the motor system. Although originally considered a pure motor degeneration, there is …
Focal thinning of the motor cortex mirrors clinical features of amyotrophic lateral sclerosis and their phenotypes: a neuroimaging study
C Schuster, E Kasper, J Machts, D Bittner… - Journal of …, 2013 - Springer
Amyotrophic lateral sclerosis (ALS) is characterised by degeneration of upper (UMN) and
lower motor neurons (LMN). We aimed to relate clinical variables to cortical thinning of the …
lower motor neurons (LMN). We aimed to relate clinical variables to cortical thinning of the …
Structural hallmarks of amyotrophic lateral sclerosis progression revealed by probabilistic fiber tractography
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive limb and/or bulbar muscular weakness and atrophy. Although ALS-related …
progressive limb and/or bulbar muscular weakness and atrophy. Although ALS-related …
Selective vulnerability of motor neuron types and functional groups to degeneration in amyotrophic lateral sclerosis: review of the neurobiological mechanisms and …
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterised by
a progressive loss of motor neurons controlling voluntary muscle activity. The disease …
a progressive loss of motor neurons controlling voluntary muscle activity. The disease …
Cortical thinning trajectories across disease stages and cognitive impairment in amyotrophic lateral sclerosis
M Consonni, E Dalla Bella, VE Contarino, E Bersano… - Cortex, 2020 - Elsevier
Background Cortical neuron degenerative process underlying upper motor neuron
involvement in amyotrophic lateral sclerosis (ALS) spreads to extra-motor regions as …
involvement in amyotrophic lateral sclerosis (ALS) spreads to extra-motor regions as …
Regional alterations in cortical thickness and white matter integrity in amyotrophic lateral sclerosis
Previous neuroimaging studies have revealed that both gray matter (GM) and white matter
(WM) are altered in several morphological aspects in amyotrophic lateral sclerosis (ALS) …
(WM) are altered in several morphological aspects in amyotrophic lateral sclerosis (ALS) …
Neurodegeneration of brain networks in the amyotrophic lateral sclerosis–frontotemporal lobar degeneration (ALS–FTLD) continuum: evidence from MRI and MEG …
F Trojsi, P Sorrentino, G Sorrentino, G Tedeschi - CNS spectrums, 2018 - cambridge.org
Brain imaging techniques, especially those based on magnetic resonance imaging (MRI)
and magnetoencephalography (MEG), have been increasingly applied to study multiple …
and magnetoencephalography (MEG), have been increasingly applied to study multiple …