OBJECTIVE To investigate serum and plasma serotonin concentrations, percentage of
serotonin-positive platelets, level of surface-bound platelet serotonin expression (mean …

Objectives Serotonin has been implicated in canine myxomatous mitral valve disease
(MMVD); however, the sources of serotonin have not been fully elucidated. This study …

Hypothesis/Objectives Altered serotonin (5‐hydroxytryptamine, 5 HT) signaling is postulated
in development and progression of canine myxomatous mitral valve disease (MMVD). Little …

Background The neurotransmitter serotonin (5‐hydroxytryptamine, 5‐HT) has recently been
suggested to play a role in the development of naturally acquired myxomatous mitral valve …

Higher concentrations of circulating serotonin have been reported in Cavalier King Charles
spaniels (CKCS) compared to other dog breeds. The CKCS is also a breed highly …

Background The neurotransmitter serotonin (5‐HT) affects valvular degeneration and dogs
with myxomatous mitral valve disease (MMVD) exhibit alterations in 5‐HT signaling. In …

Background: Increased serotonin (5HT) signaling has been implicated in valvular disease of
humans and animals, including canine degenerative mitral valve disease (DMVD). High …

Background Pulmonary hypertension (PH) in dogs with myxomatous mitral valve disease
(MMVD) is caused by increased pulmonary venous pressure. Thrombosis, vascular …

Background: Pulmonary hypertension (PH) is a common complication of degenerative mitral
valve disease (DMVD), the most common cardiovascular disease in dogs. Serotonin has …

Abstract Introduction Serotonin (5-hydroxytryptamine [5-HT]) has several biological
functions. In different species, excessive 5-HT has been linked to valvular lesions, similar to …