Frontotemporal involvement has been extensively investigated in amyotrophic lateral
sclerosis (ALS) but remains relatively poorly characterized in other motor neuron disease …

The thalamus is a key cerebral hub relaying a multitude of corticoefferent and corticoafferent
connections and mediating distinct extrapyramidal, sensory, cognitive and behavioural …

Background and Objectives To assess cortical, subcortical, and cerebellar gray matter (GM)
atrophy using MRI in patients with disorders of the frontotemporal lobar degeneration (FTLD) …

Background Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …

There is an ever growing literature on frontotemporal dysfunction in motor neuron diseases,
but the practical caveats of using imaging to evaluate extra-motor changes and linking …

Neurodegenerative process in amyotrophic lateral sclerosis (ALS) has been proven to
involve several cortical and subcortical brain regions within and beyond motor areas …

Background and purpose Primary lateral sclerosis (PLS) is a progressive upper motor
neuron disorder associated with considerable clinical disability. Symptoms are typically …

Background and Purpose This study investigated the structural and functional changes in
the motor system in amyotrophic lateral sclerosis (ALS; n= 25) and behavioral-variant fronto …

Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease (MND) that
shares a common clinical, genetic and pathologic spectrum with frontotemporal dementia …

ObjectiveAdvanced neuroimaging techniques may offer the potential to monitor disease
progression in amyotrophic lateral sclerosis (ALS), a neurodegenerative, multisystem …