The Coaching for Cognition in Alzheimer's (COCOA) trial: Study design
JC Roach, J Hara, D Fridman… - … Research & Clinical …, 2022 - Wiley Online Library
Comprehensive treatment of Alzheimer's disease (AD) requires not only pharmacologic
treatment but also management of existing medical conditions and lifestyle modifications …
treatment but also management of existing medical conditions and lifestyle modifications …
A multimodal intervention for Alzheimer's disease results in multifaceted systemic effects reflected in blood and ameliorates functional and cognitive outcomes
JC Roach, L Edens, DR Markewych, MK Rapozo… - medRxiv, 2022 - medrxiv.org
Abstract Introduction Comprehensive treatment of Alzheimer's disease and related
dementias (ADRD) requires not only pharmacologic treatment but also management of …
dementias (ADRD) requires not only pharmacologic treatment but also management of …
A systems‐biology clinical trial of a personalized multimodal lifestyle intervention for early Alzheimer's disease
SC McEwen, DA Merrill, J Bramen… - … Research & Clinical …, 2021 - Wiley Online Library
Introduction There is an urgent need to develop effective interventional treatments for people
with Alzheimer's disease (AD). AD results from a complex multi‐decade interplay of multiple …
with Alzheimer's disease (AD). AD results from a complex multi‐decade interplay of multiple …
[HTML][HTML] Multimodal interventions in Alzheimer's disease: from basic research to clinical practice
By 2050, it is projected that Alzheimer's disease (AD) will remain the prevailing variant of
dementia, affecting an estimated 131.5 million people (1). AD onset is irreversible despite …
dementia, affecting an estimated 131.5 million people (1). AD onset is irreversible despite …
Development, application, and results from a precision-medicine platform that personalizes multi-modal treatment plans for mild Alzheimer's disease and at-risk …
D Keine, JQ Walker, BK Kennedy… - Current aging …, 2018 - ingentaconnect.com
Introduction: Alzheimer's Disease (AD) is a progressive neurodegenerative condition in
which individuals exhibit memory loss, dementia, and impaired metabolism. Nearly all …
which individuals exhibit memory loss, dementia, and impaired metabolism. Nearly all …
[HTML][HTML] The Brain Health Champion study: Health coaching changes behaviors in patients with cognitive impairment
HEM Schwartz, CP Bay, BM McFeeley… - Alzheimer's & Dementia …, 2019 - Elsevier
Introduction Converging evidence suggests that increasing healthy behaviors may slow or
prevent cognitive decline. Methods We piloted a six-month, randomized, controlled …
prevent cognitive decline. Methods We piloted a six-month, randomized, controlled …
Observed improvement in cognition during a personalized lifestyle intervention in people with cognitive decline
H Sandison, NGL Callan, RV Rao… - Journal of …, 2023 - content.iospress.com
Background: Alzheimer's disease (AD) is a chronic condition marked by progressive
objective cognitive impairment (OCI). No monotherapy has substantially altered disease …
objective cognitive impairment (OCI). No monotherapy has substantially altered disease …
[HTML][HTML] The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The …
MC Norton, CJ Clark, JAT Tschanz, P Hartin… - Alzheimer's & Dementia …, 2015 - Elsevier
Abstract Introduction Most Alzheimer's disease (AD) prevention studies focus on older adults
or persons with existing cognitive impairment. This study describes the design and progress …
or persons with existing cognitive impairment. This study describes the design and progress …
Cognitively-based methods of enhancing and maintaining functioning in those at risk of Alzheimer's disease
BM Hampstead, CB Mosti… - Journal of Alzheimer's …, 2014 - content.iospress.com
Projections indicate that the prevalence of Alzheimer's disease (AD) and other dementias
will increase two to three fold in the coming decades. As a result, there has been …
will increase two to three fold in the coming decades. As a result, there has been …
Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical …
D Ornish, C Madison, M Kivipelto, C Kemp… - Alzheimer's Research & …, 2024 - Springer
Background Evidence links lifestyle factors with Alzheimer's disease (AD). We report the first
randomized, controlled clinical trial to determine if intensive lifestyle changes may …
randomized, controlled clinical trial to determine if intensive lifestyle changes may …