The Coaching for Cognition in Alzheimer's (COCOA) trial: Study design

JC Roach, J Hara, D Fridman… - … Research & Clinical …, 2022 - Wiley Online Library
Comprehensive treatment of Alzheimer's disease (AD) requires not only pharmacologic
treatment but also management of existing medical conditions and lifestyle modifications …

A multimodal intervention for Alzheimer's disease results in multifaceted systemic effects reflected in blood and ameliorates functional and cognitive outcomes

JC Roach, L Edens, DR Markewych, MK Rapozo… - medRxiv, 2022 - medrxiv.org
Abstract Introduction Comprehensive treatment of Alzheimer's disease and related
dementias (ADRD) requires not only pharmacologic treatment but also management of …

A systems‐biology clinical trial of a personalized multimodal lifestyle intervention for early Alzheimer's disease

SC McEwen, DA Merrill, J Bramen… - … Research & Clinical …, 2021 - Wiley Online Library
Introduction There is an urgent need to develop effective interventional treatments for people
with Alzheimer's disease (AD). AD results from a complex multi‐decade interplay of multiple …

[HTML][HTML] Multimodal interventions in Alzheimer's disease: from basic research to clinical practice

T Zhang, L Cong, B Chen, Z He, G Li, Q Qin - Frontiers in Neurology, 2023 - frontiersin.org
By 2050, it is projected that Alzheimer's disease (AD) will remain the prevailing variant of
dementia, affecting an estimated 131.5 million people (1). AD onset is irreversible despite …

Development, application, and results from a precision-medicine platform that personalizes multi-modal treatment plans for mild Alzheimer's disease and at-risk …

D Keine, JQ Walker, BK Kennedy… - Current aging …, 2018 - ingentaconnect.com
Introduction: Alzheimer's Disease (AD) is a progressive neurodegenerative condition in
which individuals exhibit memory loss, dementia, and impaired metabolism. Nearly all …

[HTML][HTML] The Brain Health Champion study: Health coaching changes behaviors in patients with cognitive impairment

HEM Schwartz, CP Bay, BM McFeeley… - Alzheimer's & Dementia …, 2019 - Elsevier
Introduction Converging evidence suggests that increasing healthy behaviors may slow or
prevent cognitive decline. Methods We piloted a six-month, randomized, controlled …

Observed improvement in cognition during a personalized lifestyle intervention in people with cognitive decline

H Sandison, NGL Callan, RV Rao… - Journal of …, 2023 - content.iospress.com
Background: Alzheimer's disease (AD) is a chronic condition marked by progressive
objective cognitive impairment (OCI). No monotherapy has substantially altered disease …

[HTML][HTML] The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The …

MC Norton, CJ Clark, JAT Tschanz, P Hartin… - Alzheimer's & Dementia …, 2015 - Elsevier
Abstract Introduction Most Alzheimer's disease (AD) prevention studies focus on older adults
or persons with existing cognitive impairment. This study describes the design and progress …

Cognitively-based methods of enhancing and maintaining functioning in those at risk of Alzheimer's disease

BM Hampstead, CB Mosti… - Journal of Alzheimer's …, 2014 - content.iospress.com
Projections indicate that the prevalence of Alzheimer's disease (AD) and other dementias
will increase two to three fold in the coming decades. As a result, there has been …

Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical …

D Ornish, C Madison, M Kivipelto, C Kemp… - Alzheimer's Research & …, 2024 - Springer
Background Evidence links lifestyle factors with Alzheimer's disease (AD). We report the first
randomized, controlled clinical trial to determine if intensive lifestyle changes may …