Primary lateral sclerosis (PLS) is classically considered a 'pure'upper motor neuron disorder.
Motor cortex atrophy and pyramidal tract degeneration are thought to be pathognomonic of …

Background Primary lateral sclerosis is a progressive upper-motor-neuron disorder
associated with markedly longer survival than ALS. In contrast to ALS, the genetic …

Introduction Primary lateral sclerosis is a rare neurodegenerative disorder of the upper
motor neurons. Diagnostic criteria have changed considerably over the years, and the …

Background Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which
carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite …

Background and purpose Primary lateral sclerosis (PLS) is a progressive upper motor
neuron disorder associated with considerable clinical disability. Symptoms are typically …

Objectives This is a cross-sectional study aimed at investigating cognitive performances in
patients with primary lateral sclerosis (PLS) and using diffusion tensor (DT) magnetic …

Objective: Primary lateral sclerosis (PLS) is a rare form of motor neuron disease
characterised by UMN degeneration leading to slowly progressive spasticity. Whether it is a …

Primary lateral sclerosis (PLS) has been traditionally viewed as a distinct upper motor
neuron condition (UMN) but is increasingly regarded as a sub-phenotype within the …

Primary lateral sclerosis (PLS) bears close resemblance to cases of amyotrophic lateral
sclerosis (ALS) presenting with spasticity, but histopathological studies have shown …

Primary lateral sclerosis (PLS) is a neurodegenerative disorder of the adult motor system.
Characterised by a slowly progressive upper motor neuron syndrome, the diagnosis is …