Abstract Primary Lateral Sclerosis (PLS) is an uncommon motor neuron disorder. Despite
the well-recognisable constellation of clinical manifestations, the initial diagnosis can be …

Primary lateral sclerosis (PLS) is a neurodegenerative disorder of the adult motor system.
Characterised by a slowly progressive upper motor neuron syndrome, the diagnosis is …

Primary lateral sclerosis (PLS) is a rare neurodegenerative disorder at the upper motor
neurone extreme of the spectrum of motor neurone disease. The diagnosis is clinical and …

Introduction Primary lateral sclerosis is a rare neurodegenerative disorder of the upper
motor neurons. Diagnostic criteria have changed considerably over the years, and the …

Primary lateral sclerosis (PLS) is a disorder of progressive upper motor neuron dysfunction,
in the absence of clinical signs of lower motor neuron involvement or family history …

Primary lateral sclerosis (PLS) is a controversial form of motor neuron disease (MND), with
uncertainty whether it represents a distinct clinico-pathological entity or is simply a variant of …

There is still a debate whether primary lateral sclerosis (PLS) is a distinct pathological entity
or whether it represents one end of a continuous spectrum of motor neuron disease (MND) …

Background Primary lateral sclerosis is a progressive upper-motor-neuron disorder
associated with markedly longer survival than ALS. In contrast to ALS, the genetic …

Primary lateral sclerosis (PLS) is clinically defined as a disorder selectively affecting the
upper motor neuron (UMN) system. However, recently it has also been considered that PLS …

Primary lateral sclerosis (PLS) is an extremely rare central nervous system degenerative
disorder characterized by slowly progressive upper motor neuron loss leading to severe …