Employing extracellular volume cardiovascular magnetic resonance measures of myocardial fibrosis to foster novel therapeutics
EB Schelbert, HN Sabbah, J Butler… - Circulation …, 2017 - Am Heart Assoc
Quantifying myocardial fibrosis (MF) with myocardial extracellular volume measures
acquired during cardiovascular magnetic resonance promises to transform clinical care by …
acquired during cardiovascular magnetic resonance promises to transform clinical care by …
[HTML][HTML] Myocardial fibrosis in heart failure: anti-fibrotic therapies and the role of cardiovascular magnetic resonance in drug trials
All heart muscle diseases that cause chronic heart failure finally converge into one dreaded
pathological process that is myocardial fibrosis. Myocardial fibrosis predicts major adverse …
pathological process that is myocardial fibrosis. Myocardial fibrosis predicts major adverse …
Extracellular volume associates with outcomes more strongly than native or post-contrast myocardial T1
TA Treibel, Y Fridman, P Bering, A Sayeed… - Cardiovascular …, 2020 - jacc.org
Objectives Because risk stratification data represents a key domain of biomarker validation,
we compared associations between outcomes and various cardiovascular magnetic …
we compared associations between outcomes and various cardiovascular magnetic …
Cardiovascular magnetic resonance imaging for sequential assessment of cardiac fibrosis in mice: technical advancements and reverse translation
YC Chen, G Zheng, DG Donner… - American Journal …, 2024 - journals.physiology.org
Cardiovascular magnetic resonance (CMR) imaging has become an essential technique for
the assessment of cardiac function and morphology, and is now routinely used to monitor …
the assessment of cardiac function and morphology, and is now routinely used to monitor …
Myocardial fibrosis: emerging target for cardiac molecular imaging and opportunity for image-guided therapy
FM Bengel, J Diekmann, A Hess… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Myocardial fibrosis is a major contributor to the development and progression of heart
failure. Significant progress in the understanding of its pathobiology has led to the …
failure. Significant progress in the understanding of its pathobiology has led to the …
[HTML][HTML] Detection of myocardial fibrosis: where we stand
L Zhu, Y Wang, S Zhao, M Lu - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Myocardial fibrosis, resulting from the disturbance of extracellular matrix homeostasis in
response to different insults, is a common and important pathological remodeling process …
response to different insults, is a common and important pathological remodeling process …
[HTML][HTML] Current understanding of the pathophysiology of myocardial fibrosis and its quantitative assessment in heart failure
T Liu, D Song, J Dong, P Zhu, J Liu, W Liu, X Ma… - Frontiers in …, 2017 - frontiersin.org
Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and
death. Myocardial fibrosis results from increased myofibroblast activity and excessive …
death. Myocardial fibrosis results from increased myofibroblast activity and excessive …
Myocardial fibrosis quantified by extracellular volume is associated with subsequent hospitalization for heart failure, death, or both across the spectrum of ejection …
EB Schelbert, KM Piehler, KM Zareba… - Journal of the …, 2015 - Am Heart Assoc
Background Myocardial fibrosis (MF) in noninfarcted myocardium may be an interstitial
disease pathway that confers vulnerability to hospitalization for heart failure, death, or both …
disease pathway that confers vulnerability to hospitalization for heart failure, death, or both …
[HTML][HTML] Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus …
EB Schelbert, SM Testa, CG Meier, WJ Ceyrolles… - Journal of …, 2011 - Elsevier
Background Myocardial extravascular extracellular volume fraction (Ve) measures quantify
diffuse fibrosis not readily detectable by conventional late gadolinium (Gd) enhancement …
diffuse fibrosis not readily detectable by conventional late gadolinium (Gd) enhancement …
Myocardial fibrosis: why image, how to image and clinical implications
The current era has seen major advances in myocardial imaging. We are now able to
assess cardiac anatomy, function, tissue composition and disease activity across a wide …
assess cardiac anatomy, function, tissue composition and disease activity across a wide …