Employing extracellular volume cardiovascular magnetic resonance measures of myocardial fibrosis to foster novel therapeutics

EB Schelbert, HN Sabbah, J Butler… - Circulation …, 2017 - Am Heart Assoc
Quantifying myocardial fibrosis (MF) with myocardial extracellular volume measures
acquired during cardiovascular magnetic resonance promises to transform clinical care by …

[HTML][HTML] Myocardial fibrosis in heart failure: anti-fibrotic therapies and the role of cardiovascular magnetic resonance in drug trials

M Webber, SP Jackson, JC Moon, G Captur - Cardiology and Therapy, 2020 - Springer
All heart muscle diseases that cause chronic heart failure finally converge into one dreaded
pathological process that is myocardial fibrosis. Myocardial fibrosis predicts major adverse …

Extracellular volume associates with outcomes more strongly than native or post-contrast myocardial T1

TA Treibel, Y Fridman, P Bering, A Sayeed… - Cardiovascular …, 2020 - jacc.org
Objectives Because risk stratification data represents a key domain of biomarker validation,
we compared associations between outcomes and various cardiovascular magnetic …

Cardiovascular magnetic resonance imaging for sequential assessment of cardiac fibrosis in mice: technical advancements and reverse translation

YC Chen, G Zheng, DG Donner… - American Journal …, 2024 - journals.physiology.org
Cardiovascular magnetic resonance (CMR) imaging has become an essential technique for
the assessment of cardiac function and morphology, and is now routinely used to monitor …

Myocardial fibrosis: emerging target for cardiac molecular imaging and opportunity for image-guided therapy

FM Bengel, J Diekmann, A Hess… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Myocardial fibrosis is a major contributor to the development and progression of heart
failure. Significant progress in the understanding of its pathobiology has led to the …

[HTML][HTML] Detection of myocardial fibrosis: where we stand

L Zhu, Y Wang, S Zhao, M Lu - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Myocardial fibrosis, resulting from the disturbance of extracellular matrix homeostasis in
response to different insults, is a common and important pathological remodeling process …

[HTML][HTML] Current understanding of the pathophysiology of myocardial fibrosis and its quantitative assessment in heart failure

T Liu, D Song, J Dong, P Zhu, J Liu, W Liu, X Ma… - Frontiers in …, 2017 - frontiersin.org
Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and
death. Myocardial fibrosis results from increased myofibroblast activity and excessive …

Myocardial fibrosis quantified by extracellular volume is associated with subsequent hospitalization for heart failure, death, or both across the spectrum of ejection …

EB Schelbert, KM Piehler, KM Zareba… - Journal of the …, 2015 - Am Heart Assoc
Background Myocardial fibrosis (MF) in noninfarcted myocardium may be an interstitial
disease pathway that confers vulnerability to hospitalization for heart failure, death, or both …

[HTML][HTML] Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus …

EB Schelbert, SM Testa, CG Meier, WJ Ceyrolles… - Journal of …, 2011 - Elsevier
Background Myocardial extravascular extracellular volume fraction (Ve) measures quantify
diffuse fibrosis not readily detectable by conventional late gadolinium (Gd) enhancement …

Myocardial fibrosis: why image, how to image and clinical implications

R Bing, MR Dweck - Heart, 2019 - heart.bmj.com
The current era has seen major advances in myocardial imaging. We are now able to
assess cardiac anatomy, function, tissue composition and disease activity across a wide …