Physiologically based pharmacokinetic (PBPK) models can be used to predict drug
disposition in humans from animal data and the influence of disease or other changes in …

Whole‐body physiologically‐based pharmacokinetic (PBPK) models have many
applications in drug research and development. It is often necessary to inform these models …

Simplified physiologically based pharmacokinetic (PBPK) models using estimated tissue‐to‐
unbound plasma partition coefficients (Kpus) were previously investigated by fitting them to …

Physiologically-based pharmacokinetic models (PBPK) have been used to characterize the
disposition of drugs in tissues for the past 25 years. l PBPK models are appealing in that a …

The authors compared the population pharmacokinetics of fentanyl using a standard
individualized modeling (SIM) approach versus that of a nonparametric expectation …

Pharmacokinetic modeling based on a mechanistic approach is a promising tool for drug
concentration prediction in living beings. The development of a reduced physiologically …

Predicting the pharmacokinetics of compounds in humans is an important part of the drug
development process. In this study, the plasma concentration profiles of 10 marketed …

The tissue: plasma (P t: p) partition coefficients (PCs) are important drug‐specific input
parameters in physiologically based pharmacokinetic (PBPK) models used to estimate the …

Permeability-limited two-subcompartment and flow-limited, well-stirred tank tissue
compartment models are routinely used in physiologically-based pharmacokinetic modeling …

Physiologically based pharmacokinetic (PBPK) models differ from classical PK models in
that they include specific compartments for tissues involved in exposure, toxicity …