Previous studies have shown that heteroconjugates of monoclonal antibodies in which one
of the component antibodies is directed at the T-cell receptor and the other is directed …

The T-cell receptor dictates that T cells recognize foreign antigen in the context of self major
histocompatibility complex (MHC) encoded molecules. Cells which are recognized as …

Cytotoxic T-cell clones have been shown to be capable of killing unrelated target cells in the
presence of heteroconjugates consisting of OKT3 (monoclonal antibody against cell surface …

Antibody heteroaggregates have been used to render human peripheral blood T cells lytic
for specified targets. The heteroaggregates contain anti-T3 covalently linked to antibodies …

Abstract An IgG1 monoclonal antibody, 32.2, raised against the 72,000 dalton monocyte
high affinity Fc receptor, was used to examine the role of this receptor in ADCC. This …

A simple and efficient procedure for the construction of bifunctional molecules is described
and their use in a variety of applications documented. This procedure is based on our …

Cytotoxic T lymphocytes (CTLs) normally destroy only those cells (" target cells") whose
surface antigens they recognize. However, in the presence of lectins such as Con A, CTLs …

This section will deal with the ontogeny of T cells, describing the development of
prothymocytes to pre-T thymocytes and more mature T cells. How these can be …

The cytolytic protein (C9RP) of human killer lymphocytes is immunochemically related to C9
of complement. It is probable, therefore, that the two proteins share homology in primary …

The critical role of major histocompatibility complex (MHC) gene products in T cell activation
was appreciated and extensively studied well before the availability of monoclonal T cell …