Excitatory amino acids (EAAs) administered intrathecally (it) in the mouse elicit a caudally
directed biting and scratching behavior. N-methyl-d-aspartate (NMDA) is a potent agonist …

Intrathecal injections of substance P (SP) or neurokinin A (NKA) in the mouse caused dose-
dependent reciprocal hindlimb scratching, licking and biting responses directed to the …

Rats typically display self-mutilation (autotomy) of a paw that has been denervated by
transection of the sciatic and saphenous nerves. The cause of autotomy, however, is not …

We report a nociceptive test involving peripheral irratation which produces behavior similar
to that elicited by intrathecally injected substance P. Intradermal hypertonic saline injected to …

The importace of the spinothalamic tract in pain transmission makes it an attractive
candidate for study with respect to the effects of antinociceptive compounds. We have been …

From the preceding chapters of this book, it is clear that the basic experimental work carried
out during the past 10–15 years has led to a remarkable growth in our appreciation of the …

Since the studies discussed in this chapter concern the distribution of receptors for
neurotransmitters, it is important to specify that the term “receptor” implies a physiologically …

The aging of the population of the United States in the 20th century is a well-documented
phenomenon (see, for example, Siegel, 1980; Bureau of the Census, 1983; Rice and …

Progress in most areas of pharmacology and medicinal chemistry depends upon the
availability of highly selective molecular probes. The opioid field is a case in point. With the …

Since the studies discussed in this chapter concern the distribution of receptors for
neurotransmitters, it is important to specify that the term" receptor" implies a physiologically …