Until recently, molecular analysis of inherited disorders of man has proceeded largely
through identification and characterization of specific proteins and their corresponding …

It has been clear since the rediscovery of Mendel that humans obey laws of heredity
identical with those of other organisms. The central features of Mendelism were observable …

Simple single-gene disorders in humans can be genetically mapped by using traditional
methods of linkage analysis and increasingly abundant restriction fragment length …

This paper examines the evidence for a genetic etiology of Alzheimer's Disease. Three
groups of cases are identified; the first being those with a consistently early age of onset, in …

The regulation of arachidonic acid release from membrane phospholipids was investigated
in lymphocytes from patients with cystic fibrosis as well as control patients. No effect of either …

Erythropoietin (EPO), a glycoprotein hormone, is the major physiological regulator of
erythrocyte production in mammals. A cDNA clone containing the entire human EPO-coding …

Prenatal diagnosis of cystic fibrosis was performed in 200 pregnancies with a 1-in-4 risk,
and was based on significant modifications in amniotic fluid taken at 17, 18, 19 weeks of …

We describe a general strategy for the detection of high-frequency restriction fragment
length polymorphisms in the centromeric regions of human chromosomes by molecular …

A collaborative study involving seven research groups provided an opportunity to investigate
the linkage relationships between cystic fibrosis and two DNA marker loci, MET and pJ3. 11 …

Linkage analysis with cloned gene probes has shown that the mutation causing cystic
fibrosis is located in the middle of the long arm of chromosome 7. First-trimester diagnosis of …