Intragastric behavior and absorption kinetics of a normal and “floating” modified‐release capsule of isradipine under fasted and fed conditions

N Mazer, E Abisch, JC Gfeller… - Journal of …, 1988 - Wiley Online Library
From measurements of drug levels in both gastric juice and plasma, we investigated
whether or not a prolonged gastric residence time (GRT) is responsible for the slow …

Gastric emptying of liquids in the fasted dog

PK Gupta, JR Robinson - International journal of pharmaceutics, 1988 - Elsevier
Gastric emptying of different volumes of water was studied in the fasted dog. Volumes of
water ranging from 25 ml to 500 ml at 20° C were administered during phase I of the fasted …

Improved intestinal cannula for drug delivery studies in the dog

A Rubinstein, VHK Li, P Gruber, P Bass… - Journal of …, 1988 - Elsevier
A modified light-weight intestinal cannula, based on the modified Thomas type (Thomas,
1941; Jones et al., 1971) was fabricated and tested. The design extends the useful life of the …

[图书][B] Bioadhesive polymers in drug product formulations

W Tavipatana - 1988 - search.proquest.com
Gastric retention time of single unit dosage forms in swine was found to be much longer than
in humans. It was concluded that swine are not a good animal model to study GI transit time …